Donor transmission of Cryptococcus neoformans presenting late after renal transplantation
نویسندگان
چکیده
We describe donor-transmitted Cryptococcus neoformans infection in a renal transplant recipient. The donor had no apparent risk factors for cryptococcal infection. The disease in the recipient, who did not receive prophylaxis, manifested relatively late at 50 days post-transplantation. We discuss the epidemiology and management of cryptococcal disease in solid organ transplant recipients and lessons learned from this case.
منابع مشابه
Transmission of Cryptococcus neoformans by Organ Transplantation.
BACKGROUND This article describes transmission of Cryptococcus neoformans by solid organ transplantation. METHODS We reviewed medical records and performed molecular genotyping of isolates to determine potential for donor transmission of Cryptococcus. RESULTS Cryptococcosis was diagnosed in 3 recipients of organs from a common donor with an undifferentiated neurologic condition at the time ...
متن کاملCutaneous cryptococcal infection presenting as vulvar lesion.
A woman aged 60, who had been immunosuppressed since receiving a renal transplant 17 years before, developed a painless ulcerated lesion on her right labia majora. Cryptococcus neoformans was demonstrated by culture and biopsy of the lesion. This is the first reported case of a genital skin lesion caused by C neoformans.
متن کاملDisseminated cryptococcosis presenting as cellulitis with necrotizing vasculitis.
Patients with disseminated cryptococcosis infrequently present with cutaneous involvement. Skin lesions, when present, are usually multiple and polymorphous in appearance. Cellulitis caused by Cryptococcus neoformans is rare, and necrotizing vasculitis associated with cryptococcal vascular invasion has not to our knowledge been reported. We report here a case of disseminated cryptococcosis in a...
متن کاملChemotaxis of human neutrophils and monocytes induced by Cryptococcus neoformans.
Chemotaxis of human neutrophils and monocytes was stimulated by sera activated with greater than or equal to 1.25 x 10(6) Cryptococcus neoformans. Leukocytes from five renal transplant recipients had depressed chemotactic responses to C. neoformans-activated sera when compared with normal subjects (P less than 0.05). Concentrations of cryptococcal capsular polysaccharide less than 1 mg/ml faile...
متن کاملMicrochimerism and Renal Transplantation: Doubt Still Persists
Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...
متن کامل